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Anaesthesia you can trust
An injectable anaesthetic designed exclusively for veterinary use, brought to you by Vetoquinol, a veterinary-only pharmaceutical company.
Alfaxan® is an injectable anaesthetic agent for induction and maintenance of general anaesthesia in dogs and cats. Alfaxan® is a clear, colourless, aqueous solution of alfaxalone (3-α-hydroxy-5-α-pregnane-11,20-dione), a neuroactive steroid molecule with the properties of a general anaesthetic.
The alfaxalone molecule is solubilised in the Alfaxan® formulation using 2α-hydroxypropyl beta cyclodextrin (HPBCD). Cyclodextrins are complex polysaccharides derived from starch that have a hydrophobic centre for lipophilic drugs like alfaxalone.
Unlike Cremaphor EL®, HPBCD does not cause histamine release in dogs and cats.
The primary mechanism for the anaesthetic action of alfaxalone is modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors.
Pharmacokinetics and
pharmacodynamics of alfaxalone
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Alfaxalone has a very short plasma elimination half-life in dogs and cats1,2:
• Approximately 25 minutes for a 2mg/kg dose in dogs
• Approximately 45 minutes for a 5mg/kg dose in cats
Alfaxalone is completely cleared from the body within a few hours after single administration.
Whether Alfaxan® is administered as a repeated bolus or
as total intravenous anaesthesia (TIVA) at a continuous
rate infusion, alfaxalone levels do not accumulate
and recovery periods do not appear to be prolonged3.
This supports the claim that repeated use of the product over a short period of time (for procedures lasting for up to
one hour4) does not present a risk of accumulation.
I would like to know more
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If you would like to learn more about Alfaxan®, please click on the links below :
Alfaxan® Downloads
Alfaxan® Frequently asked questions
Alfaxan® Top tips
Watch a/v Alfaxan® technical presentation
Watch videos of Alfaxan® anaesthesia |
