To view this site you must be a
veterinarian surgeon or nurse.
Are you a Veterinary Surgeon or Veterinary Nurse?

No

Putting methadone in its place in your pain management.

INTRODUCTION

Despite the high level of analgesia provided, and the fact that it has been available on the UK veterinary market since 2011, a survey performed by Hunt et al. (2015) identified that only 57.3% of veterinary practices in the UK stocked methadone, whereas 98.9% stocked buprenorphine. Factors influencing the clinician’s choice of opioid for peri-operative analgesia included analgesic efficacy, user experience, dose unfamiliarity and drug safety. These findings parallel those of the authors, especially within first opinion clinical settings.

The recent study performed by Shah et al. (2018) (reviewed in this week’s Anaesthesia1st Newsletter) as well as other previous published reports on methadone, highlight the positive qualities that methadone can afford to patients without adverse effect. Just as Shah et al. (2018) report, it is our hope that this practical summary will increase clinician familiarisation with the clinical particulars of the drug so as to increase the appropriate use of this highly efficacious analgesic in the UK veterinary setting.

PHARMACOLOGY AND CLINICAL EFFICACY

Methadone is a synthetic µ-opioid agonist which is often described in the literature as having a similar analgesic efficacy as morphine. It is licenced in the UK for use in dogs and cats and exists in formulation as a racemic mixture of the levorotatory (L) and dextrorotatory (D) isomers. The opioid analgesic effect is attributed to the L-isomer which is considered to have 10-50 times the affinity for µ-opioid receptor than its D-isomer counterpart (Kristensen et al. 1994). However, the D-isomer is considered to have an antagonistic effect on N-methyl d-aspartate (NMDA) receptors. Following tissue injury, activation of the NMDA receptor plays a key role in the development of central sensitisation and secondary hyperalgesia (i.e. an exaggerated response to painful stimuli). Further to this, some of the antinociceptive effects of methadone can be attributed to the inhibition of serotonin and noradrenaline reuptake, important neurotransmitters in the provision of descending analgesia (Murrell, 2011; Kerr, 2016). The antagonism of these pathways therefore allows methadone to provide analgesia through multiple mechanisms, conferring additional benefits over other full μ-agonist drugs and contributing to a multi-modal analgesic approach (Murrell, 2011).

It is well-known that full µ-opioid receptor agonists provide the most efficacious level of opioid analgesia. Since methadone is a full µ-opioid agonist, it elicits a maximal response at full saturation of receptor binding sites (Inturrisi, 2002) and is both effective, and indicated, for the control of moderate to severe pain (Murrell, 2011).

Plasma clearance of methadone following intravenous administration in dogs has been shown to be more rapid than that in man, meaning that the drug has a more predictable and shorter duration of effect (Ingvast-Larsson et al. 2010).  Methadone is metabolised primarily in the liver, and the terminal half-life following intravenous administration is approximately 4 hours (Murrell, 2011).

INDICATIONS AND CLINICAL USE

In the UK, methadone is licenced for use in dogs and cats for the following:

  • Analgesia
  • As part of a patient’s premedication for general anaesthesia or to provide neuroleptanalgesia when combined with an appropriate neuroleptic drug.

In addition to the above, Murrell (2011) makes the following clinical recommendations for the use of methadone in dogs and cats:

  • When moderate to severe pain is expected after surgery,
  • If mild pain is anticipated but a uni-modal analgesic approach is planned, particularly without the con-current use of non-steroidal anti-inflammatory drugs (NSAIDs),
  • When reliable and profound sedation is desired after premedication.

In dogs, the analgesic effects of methadone are superior to buprenorphine (Hunt et al. 2013; Kerr, 2016; Shah, 2018). Using a validated experimental model, methadone was also found to provide a superior level of analgesia to that provided by buprenorphine in cats (Steagall et al. 2006).

Administration of methadone may lower the requirements of other anaesthetic agents and its mode of action is dose dependent making it easy to dose to effect (Shah et al. 2018).

The licenced and data sheet recommended analgesic doses are:

  • Cats: 0.3-0.6mg/kg administered via the intramuscular route
  • Dogs: 0.5-1mg/kg via subcutaneous, intramuscular or intravenous routes

However, lower dose rates in both species are reported to provide clinically effective analgesia without some of the adverse effects that may be encountered with the top end licenced doses. These include:

  • Cats: 0.2-0.5mg/kg via the intramuscular route. Murrell (2007) recommending the use of the lower end of that dose range.
  • Dogs: 0.3-1mg/kg via subcutaneous, intramuscular or intravenous routes. Shah et al. (2018) recognising that fully efficacious perioperative analgesia can be achieved following a 0.3mg/kg dose administered intramuscularly.

The volume of distribution of methadone following administration of 0.5mg/kg intravenously in Greyhounds was greater than that found in other breeds. This in turn resulted in lower peak plasma concentrations than those seen in non-Greyhound breeds suggesting that higher doses may need to be administered in Greyhounds in order to achieve equivalent plasma concentrations of the drug.

As mentioned above, the terminal half-life of methadone when administered intravenously is approximately 4 hours and it is recognised on the product data sheet that the duration of clinical effect is estimated to be 4 hours on average in both dogs and cats. This suggests that clinically significant drug accumulation is unlikely to occur with re-dosing at 2-4 hour intervals (Murrell, 2011). Intuitively, given the lower rate of absorption following subcutaneous administration in dogs, methadone administered via this route has a longer terminal half-life than following intravenous administration (Ingvast-Larsson et al. 2010). This indicates that the dosing interval may be extended to approximately twice daily when given subcutaneously, a potential advantage when considering opioid administration immediately prior to patient discharge to the owner (Murrell, 2011). However, it must also be noted that peak plasma drug values were lower and the half-life more variable following subcutaneous administration and so compromise of analgesic efficacy must be considered. To minimise he clinical relevance of these limitations redosing via the subcutaneous route 3-4 hours following an intravenous loading dose is recommended (Murrell, 2011) 

ADVERSE EFFECTS

Opioids are cardiovascular-friendly drugs and at clinically recommended doses the cardiovascular and respiratory effects of methadone are minimal. Murrell (2011) reports that widespread experience of using methadone at doses up to 1mg/kg intravenously in both dogs and cats indicate that administration is not associated with any adverse cardiovascular effects. Bradycardia and a reduction in respiratory rate may occur when methadone is given to anaesthetised animals. Opioid induced bradycardia is produced via stimulation of the vagus nerve and can be countered if required with the appropriate administration of an anticholinergic (Murrell, 2007). 

OTHER CLINICALLY RELEVANT FINDINGS IN SELECTED LITERATURE

A retrospective study by Bini et al. (2018) compared two strategies of methadone administration for the post-operative analgesia of 136 dogs having undergone uncomplicated orthopaedic surgery. Appropriate locoregional anaesthesia had also been performed in these cases and the first dose of post-operative methadone, at 0.2mg/kg via the intravenous route, was administered 4 hours after surgery in all cases when the nerve block was expected to be wearing off. Their findings suggested that methadone administered according to the guidelines of the short form of the Glasgow Composite Measure Pain Scale (i.e. when post-operative pain scores were ≥5 out of 20 in non-ambulatory dogs or 6 out of 24 in ambulatory dogs) resulted in a level of pain management similar to those that received methadone every 4 hours post-operatively, resulted in a better food intake and did not cause post-operative vomiting.

Trimble et al. (2018) in a study comparing the sedative effects of intravenous methadone (0.2mg/kg) or butorphanol (0.2mg/kg) when either were combined with dexmedetomidine (0.002mg/kg) in healthy dogs, found that the butorphanol combination provided more profound sedation at 10 minutes post administration. No adverse events were recorded after either sedative combination.

Bitti et al. (2017) compared the sedative effects of three doses of intramuscular methadone combined with acepromazine in healthy dogs. Their results indicated that a low dose of methadone (0.25mg/kg) administered in combination with acepromazine (0.05mg/kg) will induce short-term sedation. Heavy sedation was observed in most cases following administration of 0.5mg/kg methadone in combination with acepromazine. They conclude that higher doses of methadone (0.5 or 0.75mg/kg) should be administered when prolonged sedation is desired. No clinically relevant cardiopulmonary adverse events were recorded after any sedative combination.

Slingsby et al. (2015) studied the analgesic effect of intramuscular methadone (0.5mg/kg) in combination with medetomidine (0.02mg/kg) as premedication prior to ovariohysterectomy and castration in the cat. They found that the combination of methadone and medetomidine provided adequate analgesia for the first 6 hours after administration with no adverse events. These findings were considered comparable to that of medetomidine (0.02mg/kg) when combined with either buprenorphine (0.02mg/kg) or butorphanol (0.4mg/kg). Additional analgesia was administered to all cats using intramuscular methadone (0.5mg/kg) 6 hours post premedication and subcutaneous carprofen (4mg/kg) 8 hours post premedication and was found to provide adequate analgesia for the first 24 hours post-surgery.

In a comparison of subcutaneous butorphanol (0.4mg/kg) and acepromazine (0.02mg/kg) or subcutaneous methadone (0.6mg/kg) and acepromazine (0.02mg/kg), the latter combination provided better postoperative analgesia which proved effective for up to 6 hours following ovariohysterectomy in a population of healthy cats (Warne et al. 2013)


Get your copy of the Summary of Commonly Used Peri-operative Opioids Here

opioidbanner.jpg#asset:2968

Article by
Dr. Dan Cripwell
BSc (Hons) BVSc CertAVP (EM) PgCert (VPS) MRCVS

Veterinary Technical Advisor UK
RCVS Recognised Advanced Veterinary Practitioner

Originally published: Wednesday, 7th November 2018

References

Bini, G., Vettorato, E., De Gennaro, C. and Corletto, F. (2018). A retrospective comparison of two analgesic strategies after uncomplicated tibial plateau levelling osteotomy in dogs. Veterinary Anaesthesia and Analgesia. 45(4): 557-565.

Bitti, F.S., Campagnol, D., Rangel, J.P., Junior, J.S.N., Loureiro, B. and Monteiro, E.R. (2017). Effects of three methadone doses combined with acepromazine on sedation and some cardiopulmonary variables in dogs. Veterinary Anaesthesia and Analgesia. 44(2): 237-245.

Hunt, J.R., Grint, N.J., Taylor, P.M. and Murrell, J.C. (2013). Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs. Veterinary anaesthesia and analgesia. 40(3): 297-307.

Hunt, J.R., Knowles, T.G., Lascelles, B.D.X. and Murrell, J.C. (2015). Prescription of perioperative analgesics by UK small animal veterinary surgeons in 2013. The Veterinary Record. 176(19): 493-499.

Ingvast-Larsson, C., Holgersson, A., Bondesson, U., Lagerstedt, A.S. and Olsson, K. (2010). Clinical pharmacology of methadone in dogs. Veterinary Anaesthesia and Analgesia. 37(1): 48-56.

Inturrisi, C.E. (2002). Clinical pharmacology of opioids for pain. The Clinical Journal of Pain. 18(4): S3-S13.

Kerr, C.L. (2016). Pain management I: Systemic Analgesics. In: BSAVA Manual of Canine and Feline Anaesthesia and Analgesia (Third Edition). John Wiley & Sons.

Kristensen, K., Christensen, C.B. and Christrup, L.L. (1994). The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sciences. 56(2): 45-50.

Murrell, J. (2007). Choice of premedicants in cats and dogs. In Practice. 29(2): 100.

Murrell, J. (2011). Clinical use of methadone in cats and dogs. UK Vet Companion Animal.16(5): 56-61.

Slingsby, L.S., Bortolami, E. and Murrell, J.C. (2015). Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat. Journal of Feline Medicine and Surgery. 17(10): 864-872.

Shah, M.D., Yates, D., Hunt, J. and Murrell, J.C. (2018). A comparison between methadone and buprenorphine for perioperative analgesia in dogs undergoing ovariohysterectomy. Journal of Small Animal Practice. 59(9): 539-546.

Steagall, P.V.M., Carnicelli, P., Taylor, P.M., Luna, S.P.L., Dixon, M. and Ferreira, T.H. (2006). Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats. Journal of Veterinary Pharmacology and Therapeutics29(6): 531-537.

Trimble, T., Bhalla, R.J. and Leece, E.A. (2018). Comparison of sedation in dogs: methadone or butorphanol in combination with dexmedetomidine intravenously. Veterinary Anaesthesia and Analgesia. 45(5): 597-603.

Warne, L.N., Beths, T., Holm, M. and Bauquier, S.H. (2013). Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats. Journal of the American Veterinary Medical Association243(6): 844-850.

Keep reading... More news items that may interest you.

Peri-anaesthetic management of the gastric dilation and volvulus (GDV) patient

In this article Carl Bradbrook discusses the peri-ananesthetic management of the canine gastric dilatation and volvulus (GDV) patient.

Read On...

Paper summary: Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk.

In this summary of a paper by Psatha et al (2011) we examine the clinical benefits of alfaxalone in high-risk patients when compared to the induction protocol of diazepam + fentanyl.

Read On...

Getting to the HEART of the matter - considerations for anaesthetising the cardiac patient.

In this article Miranda discusses the challenges of anaesthetising patients with cardiac disease and how protocols can be modified to accommodate these patients.

Read On...

Paper summary: How does buprenorphine compare to butorphanol for postoperative analgesia in cats?

A prospective multi-centre clinical trial comparing buprenorphine vs butorphanol for postoperative analgesia in cats.

Read On...

Paper summary: Analgesic effects of maxillary and inferior alveolar nerve blocks in cats undergoing dental extractions.

With dental surgery one of the most commonly performed procedures in small animal practice, what benefits do dental nerve blocks provide in cats?

Read On...

What should we consider when anaesthetising patients, including geriatrics, for dental procedures?

What should we consider when anaesthetising both adult and senior patients admitted for dental treatment?

Read On...

Checklist for geriatric dental anaesthesia

This article summarises and combines "Anaesthesia for the geriatric patient" and "What should we consider when anaesthetising patients, including geriatrics, for dental procedures?" into a single checklist for anaesthesia for the geriatric dental patient. A downloadable summary is also available by following the link.

Read On...

How do we recognise, assess and treat chronic pain in companion animals?

In this article Ian Self, Associate Professor in Veterinary Anaesthesia and Analgesia, School of Veterinary Medicine and Science, Nottingham, reflects on the recognition, assessment and management options for chronic pain in companion animals

Read On...

The physiology of acute and chronic pain.

In this article, which accompanies " How do we recognise, assess and treat chronic pain in companion animals?", Ian Self describes the physiology of acute and chronic pain

Read On...

What should we consider when anaesthetising the geriatric patient?

With an increasing number of anaesthetics being performed in older pets is there anything we should be aware of or do differently? In this article Carl Bradbrook examines the management of anaesthesia in geriatrics..

Read On...

Paper summary: What effect does does rapid, high volume fluid therapy have on cardiovascular function?

In this summary of a paper by Valverde (2012) we examine the effects of high-volume, rapid fluid therapy on cardiovascular function and hematological values during isoflurane-induced hypotension in healthy dogs.

Read On...

Paper summary: Pre-anaesthetic screening of geriatric dogs

In this summary of a paper by Joubert (2007) we examine the value of pre-anaesthetic screening in geriatric dogs and how the results influence the anaesthetic process.

Read On...

Anaesthesia for Canine Cushing's disease: What should we assess and what should we monitor?

Cushing's disease (hyperadrenocorticism) is relatively common in the dog and this article discusses the appropriate pre-anaesthetic assessment we should perform and why careful monitoring is essential.

Read On...

Paper summary: How frequently are intravenous catheters removed as a result of complications due to bacterial contamination?

In this summary of a paper by Ramos (2018) we examine the incidence of bacterial colonisation of intravenous catheters removed as a result of cannula complication

Read On...

What's the Point? Peripheral Intravenous Cannulation.

Peripheral venous cannulation is a common invasive procedure in small animals, but what are the best-practice insertion techniques and what can we do to avoid complications?

Read On...

Rabbit Anaesthesia – Understanding Your Patient.

How does the anatomy, physiology, behaviour and response to drugs affect your decision making when anaesthetising the rabbit patient?

Read On...

Paper summary: Heated intravenous fluids alone fail to prevent hypothermia in cats under general anaesthesia.

In this summary of a paper by Jourdan et al (2017) we examine the common practice of warming intravenous fluids and the effect on patient temperature.

Read On...

​Considerations for anaesthesia of the brachycephalic dog.

In this article Matt Gurney discusses the induction of anaesthesia and intubation of the brachycephalic patient.

Read On...

Watch the induction and intubation of a brachycephalic.

Induction of anaesthesia and intubation of a brachycephalic dog with Matt Gurney.

Read On...

Paper summary: The effect of omeprazole on oesophageal pH in dogs during anaesthesia

This summary of a publication by Panti et al., examines the effect of orally administered omeprazole on gastro-oesophageal reflux in the anaesthetised dog.

Read On...

How does a syringe driver benefit your patients?

Syringe drivers are becoming increasingly commonplace in modern veterinary practice and are a useful tool for multiple applications. This article looks at the science behind constant rate infusions and the basics of syringe driver use.

Read On...

Paper summary: Pet owner opinions about anaesthesia, pain and surgery in small animals

In this paper we explore perceptions and opinions of Canadian pet owners about anaesthesia, pain and surgery in small animals.

Read On...

Achieving Safer Anaesthesia with ASA and Joanne Michou MA VetMB DipECVAA MRCVS

How can a Veterinary version of the ASA Physical Status Classification help you achieve safer anaesthesia? To find out how watch our webinar.

Read On...

Paper summary: ASA classification and risk of anaesthetic related death in dogs and cats.

This scientific paper assessed whether the American Society of Anesthesiologists (ASA) Physical Status Classification correlated with the risk of anaesthetic death in dogs and cats.

Read On...

New! Methadyne, Our New Methadone Now Available

This is our third product launch this year, and the latest addition to our anaesthesia and analgesia portfolio, Methadyne, contains 10mg/ml methadone as its active ingredient. It can be administered for analgesia of moderate to severe pain in dogs and cats, to provide neuroleptanalgesia, and as part of a patient’s premedication protocol prior to general anaesthesia.

Read On...

A retrospective comparison of two analgesic strategies after uncomplicated tibial plateau levelling osteotomy in dogs.

In this review we summarise a publication by Bini (2018) examining two protocols for the administration of methadone following TPLO surgery in dogs.

Read On...

Practical Acute Pain Assessment

In this summary of acute pain assessment, Carl Bradbrook examines why we should be monitoring patients for pain and looks at the commonly used scoring systems.

Read On...

Alfaxan for the maintenance of anaesthesia: Peer reviewed clinical papers.

In this article we have identified the key clinical peer reviewed papers to support the use of Alfaxan for maintenance of Anaesthesia in Cats and Dogs.

Read On...

TIVA or not? (Total intravenous anaesthesia).

In this article the Jurox UK Technical Team discuss the use of intravenous agents to maintain anaesthesia in the dog and cat.

Read On...

Benzodiazepines - can they help reduce anaesthesia related side effects?

In part 4 of this series on premedicant agents we examine the pros and cons of benzodiazepines.

Read On...

Paper summary: Effect of benzodiazepines on the dose of alfaxalone needed for endotracheal intubation in healthy dogs

This paper examined whether a benzodiazepine, administered as a co-induction agent with alfaxalone, improved endotracheal intubation, and reduced the dose of alfaxalone, in the dog

Read On...

Food for Thought: Pre-anaesthetic Fasting

In this article Karen examines why we fast our canine and feline patients prior to anaesthesia and what the current recommendations are. Karen also investigates why rabbits are different and should not be starved before anaesthesia.

Read On...

​Purr-fecting Pain Management

In this article summary we examine which of the two opioids, buprenorphine or butorphanol, provides the most appropriate analgesia following ovariohysterectomy in the cat.

Read On...

Perspectives on Premeds - Phenothiazines: from Mental Health to Premedication

In this article from the Perspectives on Premeds series, Karen takes us through the properties and uses of phenothiazines in modern veterinary practice.

Read On...

Methadone with Acepromazine - when is enough, enough?

This study looks at the effects of three methadone doses combined with acepromazine on sedation and some cardiopulmonary variables in dogs.

Read On...

AceSedate®, Our New Acepromazine, Available Now.

We have extended our anaesthesia and analgesia portfolio with the launch of AceSedate®. Containing the tried and trusted, long-acting sedative agent acepromazine as its active ingredient, AceSedate can be used for the premedication, sedation and tranquilisation of cats and dogs.

Read On...

Time: is 30 minutes long enough?

This recent study examined whether the application of EMLA cream, for 30 or 60 minutes, would be a useful tool to improve patient compliance prior to intravenous cannula placement in the veterinary clinical practice setting.

Read On...

Caesarean Section Survival Guide. Part 2: Anaesthetic Protocol Selection & Peri-operative Considerations.

In this second instalment of the 2-part article, we explore premedication, induction, maintenance & monitoring, recovery and analgesia for the Caesarean section patient.

Read On...

Buprenorphine: it’s not all static in rabbits

Opioids are well known for causing gastrointestinal stasis in mammalian species. This recent paper examined the effects of a single high dose of buprenorphine on the rabbit gastrointestinal tract using non-invasive imaging techniques.

Read On...

Caesarean Section Survival Guide. Part 1: Physiology & Pre-anaesthetic Considerations.

In the first instalment of this 2-part review Karen examines the physiological changes that occur during pregnancy and how those adjustments can affect the selection of anaesthetic protocols for the increasingly common Caesarean section.

Read On...

No leeway for the spay: A comparison between methadone and buprenorphine for perioperative analgesia in dogs undergoing ovariohysterectomy.

This recent paper compares post-operative pain scores and requirement for rescue analgesia following premedication with methadone or buprenorphine, in combination with acepromazine or medetomidine, in 80 bitches undergoing ovariohysterectomy.

Read On...

Cardiac arrest - the human factor

Cardiac arrest in dogs and cats is, thankfully, relatively rare. However, when it does happen it can have devastating consequences for the animal, owner and the veterinary team. This study examined the common causalities leading up to a cardiac arrest with the aim of changing protocols to improve outcomes.

Read On...

Are you Using Safety Checklists in your Practice?

In this article, Carl focuses on the benefits of introducing a safety checklist in practice to reduce patient morbidity, mortality and to improve communication between members of the veterinary team. The article contains links to the AVA safety checklist as well as a link to a customisable list that you can adapt to your practice needs. 

Read On...

The Big Chill - Temperature Management in Sedated and Anaesthetised Patients

The effects of hypothermia are very far reaching throughout the peri-anaesthetic process. In this article, James takes us through the interesting mechanisms of body cooling and warming, the clinical relevance of hypothermia and what we can do to prevent it.

Read On...

Keeping the Finger on the Pulse -  Nuances in CV Monitoring

All patients are exposed to the risks associated with general anaesthesia. Continuously monitoring anaesthetised patients maximises patients safety and wellbeing. In this article, Dan takes us through the common monitoring techniques that provide information about the cardiovascular status of your patient. 

Read On...

Effect of Maropitant on Isoflurane Requirements & Postoperative Nausea & Vomiting

Despite being widely recognized in humans, postoperative nausea and vomiting (PONV), and the role of maropitant in reducing inhalational anaesthetic requirements have been poorly documented in dogs. This recent study evaluates PONV and isoflurane requirements after maropitant administration during routine ovariectomy in bitches.

Read On...

New! Alfaxan® Multidose Now Available

We are happy to announce we have enhanced our anaesthesia and analgesia portfolio with the introduction of Alfaxan®Multidose for dogs, cats and pet rabbits.

Read On...

Sevoflurane requirement in dogs premedicated with medetomidine and butorphanol

Little information is available about the effect that different doses of medetomidine and butorphanol may have when using sevoflurane for maintenance of anaesthesia in dogs. This recent study evaluates heart rate and median sevoflurane concentration required at different dose rates.

Read On...

Capnography II - What happened to the elephants? A summary of abnormal traces

In this second article of the capnography series, James provides a guide to a few of the most common traces that you will encounter during surgery. Scroll to the end of the article to download a printable capnography cheatsheet. 

Read On...

Pain, what a Pain! (Part 2) – Practical Tips On How To Perform Dental Nerve Blocks In Companion Animal Practice

In this second article of the Pain, what a Pain! series, Dan takes us through the LRA techniques associated with dental and oral surgery. In this article, you will find practical tips and pictures on common dental nerve blocks as well as safety concerns to consider.

Read On...

​Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits

This recent retrospective study looks at the cases of 185 pet rabbits admitted for sedation or general anaesthetic and evaluates the incidence and risk factors contributing to peri-anaesthetic mortality and gastrointestinal complications.

Read On...

Pain, what a Pain! How Locoregional Anaesthesia can Improve the Outcome and Welfare of Veterinary Patients (Part 1)

In this first article out of a series of two, Dan takes us through an introduction and practical tips for appropriate local anaesthesia delivery. Find out why these anaesthesia techniques, that are well recognised in human medicine, have seen an increase in popularity in veterinary medicine over the recent years

Read On...

Perspectives on Premeds – Opioids

Perspectives on Premeds is a series of articles touching on different pharmacological, physiological and clinical aspects of pre-anaesthetic medication. This second article aims to provide a refresher on opioids.

Read On...

Effects of Dexmedetomidine with Different Opioid Combinations in Dogs

Read the highlights of a recently published research paper that evaluates cardiorespiratory, sedative and antinociceptive effects of dexmedetomidine alone and in combination with morphine, methadone, meperidine, butorphanol, nalbuphine and tramadol. 

Read On...

Preoxygenation Study Highlights

This study evaluates the effectiveness of two methods of preoxygenation in healthy yet sedated dogs and the impact of these methods on time taken to reach a predetermined haemoglobin desaturation point (haemoglobin saturation (SpO2) of 90%) during an experimentally induced period of apnoea.

Read On...

Capnography – Not Just a Load of Hot Air

Capnography is the measurement of inhaled and exhaled carbon dioxide (CO2) concentration. The graphical illustration of CO2 within respired gases versus times is known as the capnogram.

Read On...

Perspectives on Premeds – Alpha-2 Agonists

Perspectives on Premeds is a series of articles touching on different pharmacological, physiological and clinical aspects of pre-anaesthetic medication. This first article aims to provide a refresher on α2 agonists.

Read On...

We are ‘injecting’ a bit of fun into BSAVA Congress!

We will be ‘injecting’ a bit of fun into BSAVA Congress on our stand (stand 702).

Read On...

Alfaxan - now licensed for use in pet rabbits

Jurox Animal Health is delighted to announce that Alfaxan is now licensed for cats, dogs and pet rabbits. This is an exciting advance and could change the way rabbits are anaesthetised in the U.K.

Read On...

Best Practice Rabbit Anaesthesia Roadshows

Jurox Announces eight country wide events on Best Practice Rabbit Anaesthesia

Read On...

Considerations in Rabbit Anaesthesia at the 2017 London Vet Show

Jurox to host talks on Considerations in Rabbit Anaesthesia at the 2017 London Vet Show.

Read On...

Vets needing more support for anaesthesia

Jurox research reveals that veterinary professionals have questions about their anaesthetic protocols

Read On...
Repeatable. Reliable. Relax.