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Paper Summary - Effects of alfaxalone, thiopental, propofol and diazepam on laryngeal motion in healthy dogs

Effects of alfaxalone, thiopental, or propofol and diazepam on laryngeal motion in healthy dogs
Barbara Ambros, M. Casey Gaunt, Tanya Duke-Novakovski, Susan M. Taylor, Canadian Veterinary Journal 2018 (7) p 791

What did the research find?

Alfaxalone was as good as propofol/diazepam co-administration, when administered to effect and a light plane of anaesthesia is maintained, for the purposed of evaluation of laryngeal function. There was less post induction apnoea in the Alfaxalone group (1/8) than the Propofol group (3/8) despite the use of diazepam reducing the Propofol dose used.

How was it conducted? 

Eight, medium to large, client owned, dogs were randomly assigned to receive alfaxalone, propofol and diazepam, or thiopental. All dogs were healthy with no history of respiratory disease. The study was conducted as a randomised crossover. Videolaryngoscopy was performed and still images at maximum inspiration and expiration were used to measure the area and height of the glottal gap. The normalised glottal gap area (NGGA = area in pixels/height2) was calculated. The NGAA change was defined as the difference between NGAA during inspiration and exhalation. 

Data were assessed for normality through the D’Agostino and Pearson omnibus normality test. The range of arytenoid motion was compared within groups using a Mann-Whitney test and between groups using a Kruskal-Wallis test. Times of videolaryngoscopy were compared among induction protocols using Friedman test. Statistical significance was set at P , 0.05 and power level of >= 80%.

Why is it important?

Methods for evaluating the range of arytenoid motion and changes of the glottal gap area during tidal breathing include the use of a subjective scoring system or calculation of the normalised glottal gap area from digitised images. The results of this study support the hypothesis that there is no difference in arytenoid motion, defined as change in NGGA, after the administration of alfaxalone, propofol/diazepam, or thiopental. The results are in agreement with a recent study comparing arytenoid motion after alfaxalone, propofol, andthiopental using a subjective scoring system.

Article by
James Tennant

Technical Adviser, Jurox UK

Originally published: Thursday, 16th August 2018

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